Stationary Phase Physiology Tell-Tales the Regulation of Bioactive Metabolite Production in Bacteria |Biomedgrid

Bacteria exist in a variety of physiological types, environmental habitats and niches of occurrence. In these environments, bacteria are predominantly found in the stationary growth-phase (SGP) due to oligotrophic conditions, biotic and physico-chemical stress [1]. The physiological and biochemical properties of bacteria reflect their “environmental-fitness” or adaptability to the environmental habitats i.e. extreme barophilic bacteria isolated from the deep-sea [2], a thermophilic isolate from an ultra-deep South African gold mine [3], metalophillic species from a domestic showerhead biofilm [4] plant/animal symbiotic bacteria [5,6]. The ability to survive and proliferate under such conditions depends on the physiological regulation of SGP and consequently, the synthesis of natural products/ bacterial bioactive metabolites (BBM) [7], a process intricate to the global stress-response mechanism in bacteria [8].