The Time has come turn on the Cutaneous Nerve System to manage Pain |Biomedgrid

Pain remains one the main reasons why people seek medical care. Most of the nociception leading to pain is typically generated in either the musculoskeletal system or the viscera. As the brain receives nociceptive information it will create an awareness of a noxious stimuli and respond accordingly [1]. The interconnection within the functioning of the brain, the immune system, and the health of the skin has been identified within the functioning of the brain, the immune system, and the health of the skin. Cutaneous sensory stimuli are transduced in the periphery by specialized organs or free nerve endings [2]. Primary afferent sensory neurons are long cells, often traversing distances of over 1m in humans. Nociceptive and tactile stimulation can have profound neuroendocrine effects. Nociceptive information enters the central nervous system in an organized segmentally related fashion and can produce both peripheral and central sensitization. This is a state of hyperexcitability of nerve fibers, which react to stimuli weaker than the normal threshold, spreading to adjacent nerve fibers, producing prolonged repetitive electrical discharges from a single stimulus.