The Role of TRPV1 Receptors in Vasoregulation |Biomedgrid

Transient Receptor Potential V1 (TRPV1) receptor is under investigation for several decades to develop a sensory neuron specific analgesic substance, but in contrary of the intense effort success is awaiting. A pile of experimental results gathered about the non-neural location of TRPV1 receptor in the last two decades. The physiological role of these receptor locations is not well understood and the pharmacological exploitation is not elaborated. The present review focuses on the role of TRPV1 receptors in vasoregulation and blood pressure homeostasis including Bezold-Jarisch reflex, baroreflex sensitivity, sensory neuron dependent vasodilation, endothelial cell mediated vasomotion, arteriolar Smooth Muscle Cell (SMC) related vasoconstriction and visualization of TRPV1 receptors on SMCs by reporter mice.