Anticancer Agents and Nephrotoxicity: A Mini Review |Biomedgrid

Onco-nephrology research has gained interest in the last decade because of increasing nephrotoxic effects developed by anticancer drugs. The anticancer drug developed nephrotoxicity limits the necessary treatment of the underlying malignant process of the cancer patients, and a multiple of kidney lesions develops, thus impairing the immediate survival. The kidney is an essential organ for the elimination of various antineoplastic drugs and their metabolites via glomerular filtration and tubular secretion. Thus, its dysfunction affects health and quality of life. Nephrotoxicity resulting from anticancer drugs, particularly chemotherapeutic agents, is the irreversible damage in the kidney. Chemotherapeutic agents affect the segment of the nephron leading to proteinuria, electrolyte disturbances, hypertension, acute and chronic interstitial nephritis, glomerulopathy, acute kidney injury, and sometimes chronic kidney disease. This review aims to summarise the nephrotoxic efficacy of some of the most recently developed anticancer agents and their mechanism of toxicity.