Clinical Study of Pingyangmycin Combined with Nd:YAG Laser to Treat Venous Malformations in the Oral and Maxillofacial Region

Purpose: To explore the efficacy of pingyangmycin (PYM) combined with Neodymium yttrium aluminum garnet (Nd:YAG) laser to treat venous malformations in the oral and maxillofacial region. Methods: Eighty-six patients were randomly divided into two groups. Forty-two patients were allocated to the experimental group and were injected with PYM at the lesion site, followed by Nd:YAG laser irradiation two days later. Forty-four patients were allocated to the control group and received only Nd:YAG laser irradiation (15-30W of power). All patients came back for a follow-up examination one month later. Results: Twenty-eight patients in the experimental group (66.67%) and 16 patients in the control group (36.31%) had no lesions after one treatment. Additionally, 10 patients in the experimental group (23.81%) and nine patients in the control group (20.45%) showed significant improvement at one month post-treatment. Compared to the control group, the experimental group demonstrated superior outcomes and shorter treatment durations. The between-group difference was significant (p<0.05). Conclusion: PYM combined with Nd:YAG laser is an effective treatment of venous malformations in the oral and maxillofacial region, potentially shortening treatment durations.