Systematic Review-Adverse Effects of Silver Diamine Fluoride

Purpose: To conduct a systematic review of the literature regarding the possible adverse systemic and oral effects of silver diamine fluoride (SDF) when used as a therapeutic agent for arresting caries in deciduous and permanent teeth in children and adolescents. Methods: A digital search of the adverse effects of SDF was conducted on November 25,2020 without date of publication restraints. The data was updated in February 2022 with no additional significant findings. The search was conducted using PubMed, Scopus, Cochrane Library via Wiley, EMBASE, LILACS, Biological Science Index, OpenGrey, Grey Literature Report, Dissertations and Theses, ClinicalTrials.gov, and International Clinical Trials Registry Platform. Results: The initial digital and manual systematic literature search found a total of 493 articles; after the removal of duplicates and other publications, a total of 6 publications were included in this systematic review: 3 randomized controlled trials, 2 clinical trials, and 1 ex-vivo study. SDF application was accompanied by black staining of the tooth in all six studies. There were no reports that SDF caused serious systemic illness or oral injury based on this systematic review.