Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration
Journal: RUDN Journal of Medicine (Vol.27, No. 2)Publication Date: 2023-07-03
Authors : Alexandra Pisaryuk; Elizaveta Kotova; Alexandra Moiseeva; Elvira Domonova; Natalia Tsimbalist; Imad Meray; Ayten Safarova; Tatiana Bogdanova; Natalia Tolokonnikova; Zhanna Kobalava;
Page : 195-206
Keywords : infectious endocarditis; Takayasu arteritis; aortic insufficiency; PCR-test; myxomatous degeneration; histopathologic examination; Duke criteria;
Abstract
Aortic valve lesion is a common cardiopathy, which may have very diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valve cusps associated with the development of infectious endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the structural cardiopathy associated with myxomatous degeneration and a prior IE. The presence of Takayasu arteritis has played an indirect though apparently decisive role by creating conditions for the development of immunosuppression and determining the disease severity and progression rate.
Other Latest Articles
- Respiratory system functional state in patients after the left ventricle geometric reconstruction followed by conventional respiratory rehabilitation
- Aortic-brachial stiffness mismatch as potential marker of subclinical arterial damage in patients with rheumatoid arthritis
- Arterial hypertension in young adults
- Implementation of a “seamless” model of providing specialized medical care to patients with heart failure
- MONEY MARKET OPERATIONS AND ECONOMIC DEVELOPMENT IN NIGERIA
Last modified: 2023-07-03 05:42:05