Circulating Megakaryocytes in Peripheral Blood: A Clue to Satisfactory Platelet Recovery Post Induction Chemotherapy in Acute Myeloid Leukemia
Journal: Haematology International Journal (HIJ) (Vol.6, No. 1)Publication Date: 2022-01-20
Authors : Tapas Kanti Parida Srijita Mandal Akshatha Nayak Sonali Mohapatra; Somanath Padhi;
Page : 1-3
Keywords : Platelet recovery; Induction; Chemotherapy; Prognosis; AML;
Abstract
Thrombocytopenia is a common hematological abnormality in newly diagnosed acute myeloid leukemia (AML) which may be linked to the degree of marrow infiltration by leukemic blasts as well as altered cytokine milieu in a subset of AMLs. We report the presence of circulating megakaryocytes in peripheral blood as a sign of satisfactory platelet recovery post induction chemotherapy in a pediatric subject with a favourable risk WHO category I AML with synchronous extramedullary myeloid cell tumor; and present a brief review of literature on the role of platelet recovery in AML prognosis.
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