Analytical Method Development and Validation of Tramadol Hydrochloride by Pharmaceutical Dosage Form by Ultraviolet Spectroscopy
Journal: Open Access Journal of Pharmaceutical Research (Vol.5, No. 3)Publication Date: 2021-07-13
Authors : Nidhi S; Chaudhary M;
Page : 1-7
Keywords : Validation; Tramadol; 0.1N HCL; UV spectrophotometric;
Abstract
Tramadol could be a painkiller just like an opioid. It acts within the central system (CNS) to alleviate pain. Tramadol is employed to treat moderate to severe pain in adults widely used for clinical purposes. During this respect, we aimed to develop an easy and economic UV spectrophotometric method for estimation of Tramadol Hydrochloride in bulk, injection, and tablet dosage form and validate as per ICH guidelines. Analytical research and development may be a process that assures quality attributes and internal control of the products. Tramadol shows the most absorbance at wavelength 270nm. Tramadol showed the linearity range 20-160μg per ml for this procedure with correlation (R2) was 0.9998. The current methods were found to be simple, linear, precise, accurate, and sensitive and may be used for routine internal control analysis for the estimation of Tramadol Hydrochloride bulk and tablet dosage form.
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