Canine Urinary Incontinence successfully treated by Homeopathic Medicine: A Real-world Clinical Evidence Panel Study

Background: Urinary incontinence (UI) in pets is among a group of social problems, which often leads to discomfort to the pets along with distress and financial problems to the owner. It is among the causes of requests from owners for euthanasia of their pets. The current treatments available for UI include drugs and surgery, both of which have limited efficacy, while still entailing high economic and safety concerns. Methods and Findings: This study reports the safety and effectiveness of the homeopathic medicine ‘Leaks No More' in UI. The study reported 16 neutered dogs in an older age group with a mean age of 11.15±4.40 years and percentile of max; 64.51±19.99) with heavy body weight (44.5±37.3 lb; percentile of 109.1 ± 63.8). Most dogs were females (n=12; 75%). The median dose rate was 2 drops (range 1-6) and was given to 6 (37.5%) animals through water, to 8 (50%) animals with food and to 2 (12.5%) animals by oral administration. In all, 3 (18.75%) animals were given the medicine once a day, 5 (33.33%) were dosed twice a day and 1 (6.25%) was dosed thrice a day. All 16 animals demonstrated improvement. The median time to improvement was 3 [1 - 6.25] days with a relapse reported by 2 (12.5%) owners. This relapse may be a proving of the homeopathic medicine due to excess repetition after relief of symptoms. As the sample showed significant variety, agreement analysis (Cohen's Kappa) was performed among the demographics and results from each breed viz. Mixed, Greyhound, Doberman, and Shih Tzu. The agreement analysis demonstrated inter-record agreement in most cases (Effect size = 0.71, p=0.12). Conclusion: In conclusion, the proof of concept established evidence of safety and efficacy of the homeopathic medicine 'Leaks No More', with statistics demonstrating the unbiasedness, impartiality, and reliability of the data, despite a small and high-variation sample