The Activation of DNA Damage Response is the Basis of the Occurrence, Development and Resistance to Radioor Chemotherapy in Ovarian Cancer |Biomedgrid

Genome surveillance system is critical for eukaryotic cells to maintain genome stability [1,2]. Cell cycle checkpoints is quickly activated upon detecting various forms of DNA lesions, ensued by loading of repair factors to eliminate DNA damage [3]. ATM (Ataxia-Telangiectasia mutated) and ATR (ATM and Rad 3-related), the upstream checkpoint kinase, initiate damage detection and signal transduction after exposure to genotoxic insults including ionizing radiation or chemotherapeutic reagents [4]. To eliminate DNA lesions generated during genomic replication, ATR-dependent replication stress is activated to modulates the activities of the cell cycle regulator to halt cell cycle.