Trials for – Trials Against: Analyzing Efficacy of Glucosamine and Chondroitine for Osteoarthritis

New approach to find effective remedies against osteoarthritis (OA) is actual because total treatment failure. Simultaneous existence of data explaining efficacy of glucosamine and chondroitine against osteoarthritis along with articles certifying failure of such effect raise permanent discussion. This controversy is extended with assessment of proposed infectious theory of osteoarthritis. There are several lines of suspicion for involvement of infectious factors in development of osteoarthritis and for antibacterial properties of glucosamine and chondroitine. From this view possible explanations of the trials' discrepans in GS-CS efficacy-failure against osteoarthritis follow. Along with ethiology different clinical aspects and mechanisms should not be missed in patients with OA, which may be due to infectious factors. Large meta-analysis trials may miss important information considering large non-specific cogorts of patients. There are several teaching points for further investigation in this letter. Large meta-analysis studies cannot take into account all specific groups of patients and general data may miss an important information. In order to realize a nature of osteoarthritis specific homogenous groups for each parameter should be collected and examined. Occasional data may cary light for deep mechanisms of the disease and its therapy.