DroTAG: Adapting dTAG Toolkit to Drosophila Melanogaster |Biomedgrid

Targeted protein degradation (TPD) allows an acute and reversible knockdown of protein of interest (POI) so that the direct effects of protein depletion can be studied and distinguished from secondary effects or adaptive responses [1]. Therefore, protein degradation techniques apply in studying the function of gene products in a short time frame, and rapid effectiveness can be exploited to downregulate POI in a stage-specific manner or when time is a relevant factor, including cell division.