Lineage Reprogramming: A Promising Way to Generate Hepatocytes |Biomedgrid

Hepatocyte transplantation is a promising therapy to restore the injured liver function. Currently, donor hepatocytes could be obtained by the isolation from donor liver tissues, the hepatic differentiation of stem cells, including pluripotent stem cells and liver progenitor/stem cells, the direct conversion from other type cells via lineage reprogramming. Here, we review the derived hepatocytes by lineage reprogramming, facilitating the development of efficient reprogramming methods to obtain sufficient functional hepatocytes.