Association of Vascular Endothelial Growth Factor +405G/C Polymorphism with Diabetic Retinopathy among Sudanese Patients |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.11, No. 5)Publication Date: 2021-01-20
Authors : Hoyam Yousif Hussin; Waleed Abdelateif Hussein; Sabah AE Ibrahim; Sumaya Kambal; Salih Abdelgader Almhdi; Abd Elkarim A Abdrabo;
Page : 437-443
Keywords : Diabetic; ketoacidosis; Hyperosmolar; Hyperglycaemic; Mellitus;
Abstract
Diabetic retinopathy) DR) is a major cause of new-onset blindness among diabetic adults and is characterized by increased vascular permeability, tissue ischemia, and neo-vascularization. Neovascularization of the retina carries a high risk of blindness because of vitreous hemorrhage and Vascular Endothelial Growth Factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels. Polymorphisms within the VEGF gene lead to differences in VEGF expression between individuals and could influence the etiology of a variety of pathologic conditions with which VEGF has been associated.
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