Gut-Hepatic Relationship: From Disorders of the Gut Microbiota to Hepatocellular Carcinoma |Biomedgrid

Enterohepatic relationships reflect the integrity of homeostasis regulation in the human body. Anatomical and physiological connection through the portal vein of the intestine and liver ensures the transport of products derived from the intestine directly to the liver and through the liver ensures the connection of bile and the secretion of antibodies into the intestine. However, impairment of intestinal barrier integrity, endotoxemia, increase of lipopolysaccharides in hepatocytes, Kupffer and stellate cells with increasing content of pro-inflammatory cytokines and active oxygen forms creates inflammatory environment with sensitization of liver cells to injury and profibrotic processes. The goals of experimental and clinical research in this course are multifaceted, ranging from regulating human metabolism, immune and inflammatory reactions to preventing carcinogenesis, inhibition of liver cancer progression and improving the efficiency of liver cancer treatment. Here we will discuss epidemiological issues of hepatocellular carcinoma, the role of intestinal microbiota when enterohepatic relationships are impaired, and the intestinal-associated mechanisms of carcinogenesis in this form of liver cancer.