Risk of Increased Post-Transfusion IL-8 Levels in Adult Patients with Malignancy Receiving Non-Leukodepleted Packed Red Cell Transfusions

Background: Cancer is one of the primary causes of death, and almost > 40% of cancer patients experience anemia. Transfusion serves as one of the therapies given to anemic patients. Malignancy patients with decreased immune systems which are given blood component transfusion may cause transfusion reactions (Transfusion-related immunomodulation or TRIM), the mechanism of which is suspected to correlate to inflammatory cytokines, including IL-8. Blood products with a leukocyte count of