Self Micro emulsifying Drug Delivery System A Promising Technique to Enhance the Solubility of Lipophilic Drugs

Oral route of administration has been favoured route and has dominated over other routes of administrations. However this chosen route is restricted to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40 of new chemical molecules exhibit poor aqueous solubility and exhibit a foremost challenge to modern drug delivery system, because of their low bioavailability due to its solubility. The solubility of poorly water soluble drugs can be enhanced by incorporating active pharmaceutical ingredients into oral lipid based drug delivery systems. Self micro emulsifying oil formulations are mixture of synthetic or natural oil, liquid or solid surfactant, hydrophilic solvent and co surfactant. It offers advantages like simplicity to manufacture, convenience in scale up, less interference of food on the dosage form and has the capability to deliver peptides. ying drug delivery systems SMEDDS . SMEDDS have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SMEDDS, which are isotropic mixtures used for the design of formulations to improve the oral absorption of highly lipophilic drug compounds. Conventional SMEDDS are mostly prepared in a liquid form, which can have some disadvantages. SMEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil in water emulsions. Solid SMEDDS are prepared by solidification of liquid semisolid self micron emulsifying ingredients into powders, have gained popularity. This article gives a complete overview of SMEDDS, but special attention has been paid to formulation, design, evaluation, and little emphasis on application of SMEDDS. Aditi R. Beldar | Sujit S. Kakade | Ashok V. Bhosale "Self Micro-emulsifying Drug Delivery System: A Promising Technique to Enhance the Solubility of Lipophilic Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-3 , June 2023, URL: https://www.ijtsrd.com.com/papers/ijtsrd56297.pdf Paper URL: https://www.ijtsrd.com.com/pharmacy/pharmaceutics/56297/self-microemulsifying-drug-delivery-system-a-promising-technique-to-enhance-the-solubility-of-lipophilic-drugs/aditi-r-beldar