Microbial Community of Human Skin and its Role Vitiligo Disease |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.12, No. 1)Publication Date: 2021-02-16
Authors : Mostafa AA Moustafa; Samira R Mansour;
Page : 16-21
Keywords : Vitiligo; Melanogenesis; Dysfunction melanocytes; Autoimmune disease; Melanocyte cells;
Abstract
Skin harbor a diverse group of microorganisms that live all together in a harmony forming a biofilm of human skin and named “skin microbiome”. This microbial community is dynamic in determining the health of our skin. Skin microbiome is involved in different function in which protection for our body from harmful diseases considered the most important function. Skin's healthiness can be determined by the presence of specific dominating types of microbiome. Skin microbiome can be categories into three groups of microbiome: 1. commensal (harmless and very rarely associated with disease), and 2. symbiotic (beneficial co-existence with the host without any harm), 3. opportunistic pathogens (harm and induce skin disease). Disturbance in skin microbiome is related to gut microbiome dysbiosis which leads to many skin diseases including vitiligo. This disease is resulted from destruction of melanocytes which destroy its capability for melanin production and white skin patches will appear. Theory for vitiligo development is briefly discussed.
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