Impact of Mechanical Homeostasis on the Structure and Function of the Skin |Biomedgrid

Tensional homeostasis is crucial for the morphological and functional properties of organs. Skin plays essential roles, such as waterproofing and thermoregulation. The balance of traction force is thought to contribute to the formation of strong and pliable physical structures in organs. In this mini review, we introduce our recent progress showing the importance of the balance of horizontal tension forces to proper skin structure and function by developing a functional human skin equivalent, a tensionally homeostatic skin model.