Vaccine Potential of Mycobacterium Tuberculosis ‘PE Only’ Subfamily Antigens |Biomedgrid

Mycobacterium tuberculosis (M. tuberculosis) is responsible pathogen for causing Tuberculosis (TB) infection. TB is a serious infectious disease globally and major cause of death, then other diseases. Recent WHO (World Health Organization) report estimated that approx. 10 million people became infected with TB [1]. This situation has become complicated and deadly by the arising of HIV-TB co-infection and MDR (multi-drug resistant) and XDR (extensively drug-resistant) M. tuberculosis strains, which has worsened for the prognosis and treatment of TB [2,3]. Many years of concentrated research, the Bacille Calmette-Guerin (BCG) remains only licensed vaccine against TB with variable efficacy in the adult. This vaccine provides the protection against severe meningeal TB and miliary TB in the children and infants, but ineffective against pulmonary TB in adult [4,3].