Potentiometric Sensor Based on Molecularly Imprinted Polymer for Determination of Tramadol in a Biologic Fluid Model and Urine |Biomedgrid

In this study, a potentiometric sensor based on a molecularly imprinted polymer (MIP) was developed for determination of tramadol. At optimized condition the electrode exhibited a Nernestian response (30.5±1.0 mV/decade) in a concentration range of (1×10-6 to 1×10-2 M). The potential response of the electrode was constant in the pH range of 1.0-9.0. The electrode demonstrated a response time about 15s. Selectivity coefficient of the sensor with structural similarity to tramadol was evaluated by matched potential method (MPM). The electrode was examined successfully for determination of tramadol in biological fluids and urine with a good accuracy and precision.