Overview of Determination of Imidapril Content in Pharmaceutical Preparations and Biological Matrices

Imidapril hydrochloride (IMD) is a kind of ACE inhibitor that has high activity in inhibiting angiotensin-converting enzymes. Imidapril is a new angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension. It is a prodrug-type ACE inhibitor, which means that it converts to its active form in the body. Imidapril has much higher activity compared to the ester form of imidapril. This review provides analytical methods for determining imidapril levels collected from the last twenty-one years of literature (2002–2023) through web sources such as Science Direct, Google Scholar, and PubMed, with the search keywords Analysis of Imidapril in Pharmaceutical Preparations and Biological Matrices. The methods reported are for the analysis of imidrapil in bulk, pharmaceutical preparations, and biological matrices. The analytical methods used include High-Performance Liquid Chromatography (HPLC) and UV-vis spectophotometry. Overall, the most widely used method is high-performance liquid chromatography because, not only for pharmaceutical preparations, this method can also be used for biological matrix samples that require a small amount of sample analysis.