Overexpression of miR-29b Partially Rescued the Osteogenic Differentiation and Osteogenesis Ability of Ovx-BMSCs |Biomedgrid

Osteoporosis, as a skeletal disorder characterized by gradually reduced bone mineral density, is a severe threat to millions of postmenopausal women. MicroRNAs (miRNAs) are important post-transcriptional factors and play an important role in bone degeneration such as osteoporosis and other bone-related diseases. Here we showed that the expression of miR-29b in bone tissue and bone marrow stromal cells (BMSCs) of Ovx mice is descend and overexpression of miR-29b could partially rescued osteogenic differentiation and bone formation ability of Ovx-BMSCs in vitro and in vivo, respectively. Our studies indicated that miR-29b plays an important role in regulating BMSCs osteogenic differentiation and could contribute to osteoporosis therapy.