Chronic Recurrent Multifocal Osteomyelitis Evolving into Primary Bone Marrow Hodgkin Lymphoma |Biomedgrid

Chronic recurrent multifocal osteomyelitis, a systemic inflammatory condition, prevails in children, with fever, night sweats and bone pain in the spine and to a lesser degree in the extremities. This disease is rare and is generally diagnosed with difficulty. One of the differential diagnoses thereof, the primary bone marrow Hodgkin lymphoma, displays many similarities with this disorder. However, as a malignant tumor with a poor outcome, this rare variant of classic Hodgkin lymphoma, might eventually stand out as a systemic nodal lymphoma, worsened by an HIV infection, the diagnosis being established at times with a delay as long as 17 months.