Cytokines Involved in the Progression of Liver Fibrosis by Influencing DNA Synthesis |Biomedgrid

Liver fibrosis is a pathological change in which the connective tissue in the liver proliferates abnormally, resulting in abnormal liver function or structure. Long-term liver fibrosis can develop cirrhosis or liver cancer, which poses a great threat to human health. This article reviews the cytokines closely related to liver fibrosis in recent years These cytokines affect the development of liver fibrosis mainly through processes that affect DNA synthesis. Platelet-derived growth factor promotes the division and proliferation of hepatic stellate cells by stimulating cellular DNA synthesis. Insulin-like growth factor, on the other hand, shows the proliferation of myofibroblastic cells in a manner that promotes the cell cycle to enter the DNA synthesis phase. Interleukin-6 promotes the progression of DNA synthesis in a manner that activates cyclins. We aim to find new approaches for the treatment of liver fibrosis by means of regulating DNA synthesis as the main approach by summarizing existing studies.