Procarcinogenic effect of Ginkgo biloba L. extract in a hepatocarcinogenesis model |Biomedgrid

Currently, hepatocellular carcinoma (HCC) is one of the leading causes of death worldwide. Among the treatment alternatives are phytomedicines. Ginkgo biloba extract (EGb) is a herbal medicine with antioxidant and antiproliferative properties reported in different “in vitro” models of cancer, so, it could be used to treat HCC. However, recent studies show that it can also have carcinogenic effects. Therefore, through the quantification of the enzymes ALT and AST, serum markers of hepatocellular damage, the impact of EGb was evaluated in a model of hepatocarcinogenesis in the initiation and promotion stages in male rats of the Wistar strain. For this, 21 two-month-old Wistar male rats were used, separated into seven groups. The administration of DEN induced hepatocarcinogenesis for the initiation stage and 2-AAF for the promotion stage.