INFILTRATION ANAESTHESIA FOR TYMPANOPLASTY: A COMPARISON OF DEXMEDETOMIDINE AND CLONIDINE AS ADJUVANTS TO LIGNOCAINE AND ADRENALINE

Background: For many decennia, local anaesthetics have been utilised for wound infiltration analgesia. α -2 Adrenoceptors as adjuvants have an advantageous effect in prolonging the time of peripheral nerve blocks is a locally mediated action and not replicated by given systemically. An increasing impact on lignocaine-induced suppression of the C-fibre action potential is thought to be the cause of its synergistic activity with lignocaine in extending the duration. we evaluated Dexmedetomidine and clonidine when administered with lignocaine during infiltration anaesthesia for tympanoplasty. Methodology: 50 patients of 18-60 years who were enrolled for tympanoplasty under local anaesthesia were arbitrarily split into two equal groups. 12 ml of 2% lignocaine with adrenaline + clonidine + 1 ug/kg were injected into Group C (n = 25), and 12 ml of 2% lignocaine with adrenaline + dexmedetomidine + 1 ug/kg were injected into Group D (n = 25). Hemodynamic parameters, sedation score, analgesia onset and duration, and bleeding severity were all chronicled. No differences in terms of analgesias onset, Boezaart score, or its impact on hemodynamic parameters were observed. Dexmedetomidine protracted the duration of postoperative analgesia 1183.2±343.59 min in comparison to clonidine 766.4±185.89min and with high sedation scores. Conclusions: Dexmedetomidine was found to be superior to clonidine when used as an adjuvant to local anaesthetic in infiltration anaesthesia for tympanoplasty, with no difference in terms of onset of analgesia, grade of bleeding, or hemodynamic parameters.