Significant Effects of CCR5delta32 Polymorphism on Alzheimer‘S Disease, Neurological Disorders, Cancer, Diabetes and Viral Infection in the Worldwide Population |Biomedgrid

The CCR5delta32 allele is a mutation in the sequence encoding CCR5 that leads to a loss of expression of this chemokine receptor, normally expressed on immune cells. The CCR5delta32 allele is known to provide protection against HIV and is involved in numerous diseases, including Alzheimer's disease. This study explored CCR5 involvement in different diseases by comparing CCR5delta32 allele frequency to the overall number of registered deaths attributed to Alzheimer's disease and neurological disorders, cancer, diabetes and viral infection in the worldwide population. Accordingly, we revealed significant positive correlations between CCR5delta32 allele frequency and Alzheimer's disease, numerous neurologic diseases and cancers but negative correlations between CCR5delta32 allele frequency and diabetes and viral infection. Our results thus highlight the differential involvement of the CCR5 receptor in various diseases and its importance as a potential therapeutic target. Moreover, this study emphasizes the importance of delineating the involvement of CCR5 in complex diseases and deciphering the mechanism of its actions.