Betting on Metformin and their Signature Modality in Realm of Cancer Therapy| Biomedgrid

Natural products and their synthetic analogs have played an integral role in drug discovery, mostly for cancer and other infectious diseases and over 60% of currently available anticancer drugs are from natural sources [1,2]. Plant-based compounds that show antitumor properties belong to various groups of compounds, such as alkaloids, diterpenes, diterpenoquinone, purine-based compounds, lactonic sesquiterpene, peptides, cyclic depsipeptide, proteins, and macrocyclic polyethers. One of the most famous plant-based drugs is metformin, used as antihyperglycemic drug, which was isolated from Galega officinalis [3,4].