SCREENING OF ANTI-OBESITY POTENTIAL OF HIPPEASTRUM VITTATUM FLOWER EXTRACT IN EXPERIMENTAL RATS

Obesity as an “abnormal or excessive fat accumulation that may impair health,” further clarifying that “the fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. The phytochemicals and anti-obesity effect of Hippaestrum vittatum experimental rats was evaluated. A growing number of people are turning to the plant genus Hippeastrum, which contains several alkaloids, as a remedy for neurological disorders and neurodegenerative diseases. The most widely grown amaryllis in the world, Hippeastrum vittatum, is native to Central and South America, Brazil, and Peru. A botanist was able to correctly identify and certify H. vittatum flowers that were collected in the Unnao region. The obtained extract was determined for preliminary phytoconstituents and then evaluated for anti-obesity activity. Albino rats (both sexes) between 130 and 160 g were provided by the Animal House at the Institute of Pharmaceutical Sciences and Research in Unnao. Rats were divided in 5 groups i.e., control, disease control, standard test 1 and test 2. All the rodents were tested for parameters i.e., Body Weight (Gross), Weight of body organs i.e., Liver, Kidney, Brain, Lipid profile and total cholesterol level, Food consumption pattern, Blood glucose level and Antioxidant activity. In all the parameters, H. vittatum showed a significant modulation in order to confirm its anti-obesity potential. It lowered body weights of rodents when compared with the control at both the doses of 200mg/kg and 400mg/kg. Body organ weights also got decreased when measured at the spleen, liver and kidneys. Thus, by all the factors and protocols, it can be concluded that H. vittatum is an important and effective anti-obesity substance that be given in human beings after clinical trials demonstrating optimum safety and efficacy parameters. It would be very impactful with easier way of curing obesity, hypercholesterolemia and high-fat due to its wide availability and action.