Simulation of a multiscale model of the Heart |Biomedgrid

The heart is comprised of four chambers, which function due to pressure changes across each chamber during the cardiac cycle. When observed at the microscopic level, these pressure changes are generated by calcium and troponin C binding in the cross-bridge cycle of a sarcomere. This binding creates a ratchet and stroke interplay which creates contraction in the muscle. This contraction exerts a force which in the heart causes the chambers to generatea force. This force creates pressure changes to move the fluid (blood) from one chamber to another. The method used in this report incorporates these considerations to model the pressure volume curves of the left ventricle and left atrium. The other chambers are modeled using the elastance theory. This article includes a literature review of several aspects of the cardiovascular system from the molecular to the anatomical level and simulates the cardiovascular system using a multiscale model inspired from previous articles and compliments what has been previously described [1–9]. Data acquired will be reproduced and analyzed using MATLAB.