Repeat Treatments for Fertile PGD Couples - When to Quit |Biomedgrid

The vast evolution in in vitro fertilization (IVF) and human genetics over the past 30 years made it possible to develop preimplantation genetic diagnosis (PGD) for couples' carriers of genetic diseases. The indications for PGD are genetic disorders with a risk of ≥25% for offspring to be affected by monogenic diseases with recessive, dominant and X-linked inheritances, translocations or other chromosomal aberrations. This technology is wildly accepted as being robust, sensitive and highly accurate, precluding misdiagnosis by allowing the amplification of both the familial mutation and several flanking informative polymorphic markers [1,2], thereby dramatically reducing the risk of misdiagnosis due to allele dropout of the mutated allele [3]. Thus, although these couples are usually fertile, PGD ensures the birth of an unaffected child and avoid pregnancy with affected fetuses that obligate termination of the pregnancy.