TYG-BMI AS A SURROGATE MARKER IN HYPERTENSIVE PATIENTS - AN OBSERVATIONAL STUDY IN TERTIARY CARE HOSPITAL

Background: Previous epidemiological studies have shown that the triglyceride-glucose index (Ty-G) was well- known predictor for the development of diabetes mellitus. A study proposed that traditional lipid ratios, particularly the TGHDL- C ratio based on the proportion between pro atherogenic and anti-atherogenic fractions are more effective than single lipids measure in identifying IR. Ty-G index predicted the subsequent occurrence of HTN in a positive and dose-dependent manner. Therefore, early detection of the Ty-G index may be beneficial for early interventions to prevent HTN among the Chinese population Methodology: The present study was an observational study and the results of total 128 hypertensive patients and healthy volunteers aged between 35 to 60 years was collected from a Tertiary care hospital. Body mass index (BMI), Waist Circumference (WC), blood pressure, fasting blood glucose and Triglyceride levels were measured. Receiver Operating Characteristic (ROC) Curve was used to check association between the study groups. Results: ROC curve based on sensitivity and specificity with reference to TyG-BMI as dependent variable among the groups. Area under curve for Waist/Hip ratio(W/H) was 0.543, HbA1c was 0.766, albumin/creatinine was 0.512, aspartate aminotransferase/alanine aminotransferase was 0.528, triacylglycerol/high density lipoprotein was 0.681 with cut-off value of W/H is 0.81, HbA1c is 5.05, albumin/creatinine is 2.56, AST/ALT is 0.41, TAG/HDL is 0.71 respectively. TyG-WC as dependent variable in normotensive and hypertensive subjects, area under curve for W/H was 0.626, HbA1c was 0.671, albumin/creatinine was 0.527, AST/ALT was 0.528, TAG/HDL was 0.681 with cut-off value of W/H ratio is 0.80, HbA1c is 5.05, albumin/creatinine is 2.56, AST/ALT is 0.55, TAG/HDL is 1.64 respectively. Conclusion: Our observational study suggests that higher Ty-G index was associated with higher probabilities of hypertension in general adult population. Large-scale prospective cohort studies are looked-for to elucidate the latent pathophysiological mechanisms underlying the association among Ty-G index and hypertensive subjects.