Gene Associated Divergence of COVID-19 Morbidity & COVID-19 Vaccines |Biomedgrid

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), also known as COVID-19, drastically changed our everyday lives. It has indeed caused a considerable increase in morbidity and mortality rates worldwide. There is an underlying complex interplay between the infectious agents and the human host, which is related to different biological mechanisms. Phenotypic spectrums associated with SARS-CoV-2 infection or COVID-19 range from asymptomatic to severe systemic complications such as pneumonia, respiratory failure, and death. Around 15 % of cases are severe. Some are accompanied by a dysregulated immune system or a cytokine storm, and others with both. There is increasing evidence that the severe manifestations of COVID-19 might attribute to human genetic variants. Polymorphisms in genes that are related to immune deficiency and or inflammasome activation (cytokine storm) are examples of these variants.