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STRUCTURAL CHARACTERIZATION OF THE MUTANTS OF LAMINA ROD2 BDOMAIN

Journal: International Journal of Advanced Research (Vol.11, No. 09)

Publication Date:

Authors : ; ;

Page : 494-501

Keywords : ;

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Abstract

LaminAbelongstotypeVintermediatefilamentproteinfamilyandispresentinallmetazoan cells except plants. Lamins provide structural rigidity to the nucleus, tether thechromosomesandmaintainhomeostasisbyplayingdiverserolesinreplication,Transcription,andDNAdamagerepair.Overthelasttwodecadestherehasbeenatremendous impetus in the research involving laminsdue to the fact that an overwhelmingnumber of mutations have been uncovered in LMNA gene which leads to a plethora ofdiseasescollectivelytermedaslaminopathies.Laminopathicnucleiinthepatientsarecharacterizedbytheirmisshapennatureandfragilityduetoimproperlaminaformationunderneath the nuclear envelope. Almost 450 mutations of lamin A have been reported inpatients worldwide. This article uncovers the structural differences of Rod 2B R377L &R377C with respect tothe wild type.

Last modified: 2023-10-19 17:44:50