A RARE CLINICAL CASE SERIES OF LEIOMYOSARCOMA OF SOFT TISSUE ORIGIN AT OUR INSTITUTE

Introduction:- LMS is a type of rare cancer that grows in the smooth muscles of the body. LMS is a aggressive cancer. LMS incidence is between 5-10% of soft tissues sarcoma cases and is more common in adults. It often present as an enlarging painless mass. Imaging with proper Biopsy and IHC aids in the diagnosis and management incudes a multidisciplinary approach. Objectives:- Due to rarity of this disease case series of LMS of soft tissue origin is documented here. Material and Methods:- 3 cases of primary LMS of soft tissue origin is documented in this case series along with history, imaging, diagnosis and treatment. 1. LMS of Lung – A 51 year old female patient presented with complaints of cough and difficulty in breathing since 3-4 months. Patient was planned with chemotherapy. 2. LMS of Pelvis – A 44 year old female patient presented in OPD with complaints of pain in leg due to nerve compression. Patient underwent surgery followed by which chemotherapy was given. 3. LMS of Pararenal Space – A 33 year old female presented with dull aching pain in left lumbar region since 2-3 months. Patient managed with surgery, chemotherapy and radiotherapy. Conclusion:- Due to rarity of the sites of LMS mentioned in the case series little is known about its clinical behaviour and treatment outcome. A multidisciplinary approach is needed for the optimal management of the disease. Surgery with a curative intent is the corner stone of treatment for localized disease along with the combination of neoadjuvant or adjuvant chemotherapy and radiotherapy. Due to its aggressive behaviour and rarity, further researches are required for the definitive treatment.