PRAPOUNDAREEKADI GHRITA, A NOVEL FORMULATION FOR THE MANAGEMENT OF PARIKARTIKA (ACUTE ANAL FISSURE)

Anal fissure is a common medical condition characterized by a tear or ulcer in the anal canal. It comprises 10-15% of anorectal disorders. The healing process of an acute anal fissure differs from that of a typical acute wound due to continuous contamination of the fissure and reduced blood supply caused by sphincter spasm, leading to chronicity. Currently available treatments include conservative measures, such as dietary changes and stool softeners, as well as topical medications and surgical interventions. However, these treatments often have drawbacks, such as limited efficacy, adverse effects, and invasiveness. The purpose of this research was to evaluate the comparative efficacy of Prapoundareekadi Ghrita and Jatyadi Ghrita in the management of acute anal fissure. The study findings indicate that Prapoundareekadi Ghrita is as effective as Jatyadi Ghrita in the management of acute anal fissure with an overall efficacy of 90% in promoting healing and relieving symptoms. No adverse reactions were observed in either group, highlighting the safety profile of the trial drug. In conclusion, Prapoundareekadi Ghrita represents a convenient and therapeutically efficient alternative for the treatment of acute anal fissure. Its simplicity in formulation, containing fewer ingredients compared to the controlled drug, renders it a superior option in this context. The study results support the use of Prapoundareekadi Ghrita as an effective and safe treatment option, potentially addressing the drawbacks associated with current treatments for anal fissure.