EFFECT OF RED GUAVA (Psidium guajava L.) LEAVES EXTRACT ON PARACETAMOL ANALGESIC ACTIVITY IN MALE WHITE MUSCULES (Mus musculus)

Many people have the opinion that the use of herbal medicines that are used together with chemical drugs is considered safe and does not cause side effects that are harmful to health. In general, all diseases can cause pain. The state of pain is a sensory and emotional event that is uncomfortable to feel due to tissue damage. Plants from nature that are often used for analgesic therapy are guava plants, tropical plants from the Myrtaceae family. This study aimed to determine the activity of red guava leaf extract (Psidium guajava L.) and its combination against paracetamol tablet analgesics in white male mice (Mus musculus). This research method is an in vivo experimental method which consists of making red guava leaf simplicia, red guava leaf extraction, phytochemical screening, and analgesic activity test. The results of this study were red guava leaf extract with a dose of 200 mg/kgBW was able to provide a pain barrier of 49.59% and red guava leaf extract combined with paracetamol at a dose of 65 mg/kgBW gave a pain barrier of 76.42%.