The Interaction of Podocytes, Glomerular Cells and Mesangial Cells in Glomerulopathies |Biomedgrid

Glomerular disease is the collective term to designate diseases that affect the structure and function of the glomerulus [1]. The causes of this entity are divided into primary or secondary. Generally, it is not an easy task to differentiate them because of their various forms of presentation, which vary in severity from asymptomatic urinary abnormalities to acute kidney injury (AKI) or end-stage renal disease (ESRD) [2] Primary glomerulopathies refer to those entities in which renal involvement is not the consequence of a more general disease and the clinical manifestations are restricted to the kidney. The five most important types of primary glomerulopathies are minimal lesions, focal segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy and membranoproliferative glomerulonephritis. In this subset of glomerular diseases there are 3 factors that contribute to its genesis, however in most of them the antigen or the ultimate cause of the disease is unknown [1,3].