Tongue Hyperpigmentation Induced by Cyclophosphamide and Doxorubicin: Case Report |Biomedgrid

Background Antineoplastic chemotherapy is associated with many side effects including mucosal and cutaneous manifestations. Nail and mucosal pigmentation are examples of these side effects. Case presentation We present a 46-year-old Saudi female with breast cancer who experienced hyperpigmentation of tongue secondary to doxorubicin and cyclophosphamide used for her disease. Patient complained of painless tongue hyperpigmentation that appeared after second cycle of chemotherapy administration. The tongue had normal texture with no swelling or swallowing difficulties. She was diagnosed with chemotherapy-induced tongue hyperpigmentation and advised with good mouth hygiene and antiseptic mouth wash. The dark lesions were constant in the shape, colour and size until the end of chemotherapy administration. After few months of the end of her chemotherapy treatment, the tongue hyperpigmentation disappeared spontaneously without any treatment.