ANTIHYPERLIPIDEMIC EFFECT OF CORN SILK ETHANOL EXTRACT (Stigma maydis) ON HIGH FAT DIET INDUCED WHITE RATS

Hyperlipidemia is a state when there is an elevation in total cholesterol, triglycerides, Low Density Lipoprotein (LDL) and a reduction in High Density Lipoprotein (HDL) levels. The aim of this research is to investigate the antihyperlipidaemic effects of corn silk and determine the effective dosage of corn silk for reducing cholesterol, triglycerides, LDL and increasing HDL levels in male rats induced by a high-fat diet and PTU. This experiment utilized 24 male Wistar rats divided into six groups, each consisting of individuals aged 2-3 months and weighing between 200 and 250 grams. The groups were labelled as follows: negative control (Na CMC0.5%), positive control, comparison (simvastatin), and treatment I, II, III (with extract doses of 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW). The rats were administered a high-fat diet and propylthiouracil for a period of seven days to induce an increase in cholesterol levels. For the subsequent seven days, the extract was administered. The study results demonstrate that corn silk extract can significantly decrease cholesterol by 46%, 49% and 51%, and LDL by 57%, 61% and 67%, and that corn hair extract can decrease triglycerides by 60%, 65% and 67%, and increase HDL by 21%, 24% and 28%. Thus, it can be concluded that corn silk extract possesses antihyperlipidemic activity with significant value (p<0.005), and the most effective dose for lipid reduction is 150 mg/Kg BB.