Positive Correlation Found Between CXCL12/PLK1 Expression and T Stage of Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and the incidence is steadily increasing. T Stage is one of the most important information to assess the disease magnitude. Both CXCL12 and PLK1 play important role in several pathways that lead to proliferation of tumor cells. The disruption of this pathway is seen in many cancers including clear cell renal cell carcinoma. This research aimed to describe the expression and the correlation between CXCL12 and PLK1 in various T stage of ccRCC. This was an analytic observational study with cross-sectional approach. The study included 50 samples throughout January 2014 until June 2022. The samples were divided into T1, T2, T3, and T4 based on histopathology examination. Immunohistochemistry examination was performed using CXCL12 and PLK1 antibodies. The correlation was analyzed using statistical tests. There was positive correlation between CXCL12 and PLK1 expression in various T stage of ccRCC (p=0.005), but when correlated separately, there was no significant result in both CXCL12 and PLK1 (p=0.443 and p=0.292, respectively). CXCL12 and PLK1 expression varied throughout different T stages in this study, but in tandem, the work of CXCL12 positively affect PLK1, resulting greater tumor size.