EXPLORING THE MEDICINAL MARVEL: THE POTENTIAL OFYARSAGUMBA AS REGENERATIVE MEDICINE AND IN WOUND HEALING

Yarsagumba(Cordyceps mushroom) a valued herbal medicine, is a fungus that grows on ghost moth larvae. It belongs to the Ophiocordycipitaceae family and has been used in traditional Chinese medicine for centuries. It has various applications in the pharmaceutical and health industries. In Nepal, Yarsagumba has been recognized for thousands of years and is considered one of the most promising medicinal mushrooms. Scientists have been studying its unique life cycle and medical uses for the past 30 years.However, once correctly identified, these enigmatic organisms hold great promise in the prevention and treatment of numerous ailments such as cancer,woundhealing, antidiabetic, alleviating fatigue, respiratoryproblems, and erectile dysfunction in men.Cordyceps fungi possess significant phytochemicals, namely cordycepin and adenosine, which function by suppressing the adenosine A2 receptor and consequently inhibiting various neuroinflammatory markers such as NF-κB, NLRP3 inflammasome, IL-1β, iNOS, COX-2, TNF-α, and HMGB1. Yarsagumbas wound healing properties are multifaceted, with its anti-inflammatory and antioxidant compounds reducing inflammation and preventing tissue damage. Its immunomodulatory effects enhance the bodys immune response and inhibit the growth of harmful microorganisms, reducing the risk of infection. Yarsagumbas regenerative capabilities stimulate collagen production and promote angiogenesis, resulting in improved wound healing outcomes and minimized scarring. This review examines how Yarsagumbas bioactive compounds can enhance wound healing, reduce scarring, and improve tissue repair. It also explores the plants regenerative properties, such as its ability to stimulate stem cell growth and differentiation. Our findings indicate that the activation of adenosine receptors by adenosine and cordycepin effectively triggers the Wnt/β-catenin signaling, which can potentially facilitate tissue remodeling and serve as a therapeutic approach for skin wound treatment.