ISOLATED D-PINITOL FROM AERIAL PARTS OF SOYBEAN PLANTS PLAYS A PROTECTIVE ROLE ON DOXORUBICIN INDUCED CARDIOTOXICITY IN MICE MODEL: HISTOPATHOLOGICAL STUDIES OF HEART

Introduction:D-Pinitol, a polyol is a potent antioxidant agent and anti-inflammatory agent. Hence,this study was carried out to evaluate whether D-Pinitol administration prior to induction of cardiotoxicity using Doxorubicin would protect cardiac histopathological changes in an experimental mice model. Methods: Ten groups of sixty Swiss Albino mice were taken for administration: Control, Doxorubicin (5 mg/kg), D-Pinitol (400 mg/kg, 300 mg/kg, 200 mg/kg & 100 mg/kg), and D-Pinitol (400 mg/kg, 300 mg/kg, 200 mg/kg & 100 mg/kg) + Doxorubicin (5 mg/kg). DOX-induced cardiac toxicity was characterized by the histopathological observations. Results: Myocyte necrosis was clearly seen in the group that received just doxorubicin therapy. Administering D-Pinitol before receiving Doxorubicin minimized myocyte necrosis and degeneration of myocytes. Conclusions:Administration of D-Pinitol to Doxorubicin-challenged rats ameliorated alterations in histological cardiac damage compared with the Doxorubicin alone treated group. As a result, D-Pinitol supplements may help lessen the cardiac damage caused by doxorubicin.