DRUG INTERACTION BETWEEN MELOXICAM AND MAJOON SURANJAN (A POLYHERBAL UNANI FORMULATION)

Majoon Suranjan (MS) is a polyherbal formulation used in Un ani system of medicine for the treatment of rheumatoid arthritis (RA). It is prescribed by unani practitioners and there is no objectionon the concomitant use of this formulation along with conventional NSAIDs. Present study deals with the pharmacodynamics interaction of conventional NSAID with majon suranjan. Interaction was studied by the influence on the anti - inflammatory activity of the standard drug in turpentine oil induced paw edema, and anti - arthritic activity in formaldehyde and complete fruend’s adjuvant induced arthritis. In all these three methods meloxicam was used as the standard conventional NSAID . 3 Groups of male whistar rats (n=6) were used in this study. Group I received vehicle, Group II received meloxicam and III received combination u se of meloxicam and majoon suranjan. In turpentine oil induced rat paw edema anti - inflammatory activity of group III is superior to Group II. Anti arthritic activity of group III is less when compared to Group II in formaldehyde and adjuvant induced arthr itis models. Data of these three methods are analysed by annova and dunnetts multiple comparison at p<0.05 in turpentine oil indued rat paw edema and p<0.01 in formaldehyde and adjuvant induced arthritis models. Results suggest that there exist an interact ion between conventional NSAIDs and polyherbal formulation whether it may be positive or negative type. These results suggests that based on the pathology of disease interaction of NSAIDs with polyherbal formulation differs. In present study anti inflamma tory acivity of drug increased while anti arthritic activity decreased. Keywords : Majoon Suranjan, meloxicam, Turpentine, Formaldehyde, NSAIDs, adjuvant induced arthritis