The Synthesis and Characterization of a Novel Ligand Derived from Pyrrolopyrimidine, Along with its Complexes with Mn(III), Fe(III), Co(III), Cr(III), Ru(III), Ir(III), and Pt(IV)

— The synthesis of 4-[2-(2-fluorobenzylidene)hydrazinyl]-7H-pyrrolo[2,3-d]pyrimidine (HPPHoFB) involved the interaction of pyrrolopyrimidinehydrazide and o-fluorobenzaldehyde. The ligand was used to generate bis-chelate complexes of Mn(III), Fe(III), Co(III), Cr(III), Ru(III), Ir(III), and Pt(IV) by employing chloride/sulfate salts in alcohol. The HPPHoFB ligand and its metal complexes were characterized by microanalyses, FT(IR), NMR, UV-Vis spectroscopy, magnetic susceptibility, and conductance studies. With the exception of Pt(IV) complex, which possesses a square planar metal center, it has been suggested that all other complexes have an octahedral geometry. HPPHoFB ligand forms a bond by means of a nitrogen atom. The x-ray powder diffraction studies of all complexes are also described. The antibacterial efficacy of the newly synthesized compounds against gram-positive, gram-negative, and fungi was investigated using the microdilution technique. The Co(III) complex exhibited potent and specific antibacterial action at concentrations of 50-70 mgmL-1 against Bacillus subtilis MCC 2010, and Staphylococcus aureus MCC 2408, which are Gram-positive bacteria capable of generating spores. However, it did not show any antibacterial effects against Candida species. The Co(III) complex has the potential to serve as a new and effective antibacterial agent specifically targeting gram-positive bacteria