STUDY OF ORAL SQUAMOUS CELL CARCINOMA IN CORRELATION WITH P16 IHC MARKER

Introduction: Oral squamous cell carcinoma consistently ranks as one of the top seven cancers world wide. P16 expression is now being used as surrogate marker of HPV infection in squamous cell carcinoma. Aims:To study and correlate oral squamous cell carcinoma in indianpopulation with age, sex, habit of tobacco, anatomical site, histological grade and scoring of p16 positivity on IHC. Material and methods:100 cases oforal squamous cell carcinomawere correlated withp16 IHC marker positivity with age, sex,habit of tobacco, anatomical site and grading of squamous cell carcinoma and scoring of p16 positivity on IHCbased on system by M. Oliver et, al. Result:Out of 8 p16 expression positive cases: 3 cases were< 50 years of age while 5 cases observed in > 50 years of age. M:F ratio was 7:1.2 cases were tobacco chewers and 1 case was smoker, numbers of welldifferentiated, moderately and poorly differentiated cases were 2,4 and 2 respectively, Out of total 100 cases of oral squamous cell carcinoma 92cases with 0 score of p16 immunostaining,3 cases with 1+,2 cases with 2+ and 3cases with 3+ scores observed.