THE CORRELATIONS BETWEEN THE THYROID STATUS INDICATORS AND THE PARAMETERS OF COMPLETE AND BIOCHEMICAL BLOOD TESTS IN MALES WITH ACUTE INFECTIOUS PULMONARY DESTRUCTION

Background. Acute infectious pulmonary destruction (AIPD) is characterized by the presence of a pronounced intoxication syndrome, with the development of anemia, disorders of protein and lipid metabolism as well as other types of metabolism. Thyroid hormones play an important role in regulating metabolic processes in the body. Aim. To study the correlations between the thyroid status indicators and the parameters of complete and biochemical blood tests in males with AIPD. Material and methods. The serum levels of total triiodothyronine, total thyroxine, free thyroxine and thyroidstimulating hormone were measured in 80 males with AIPD and 30 apparently healthy male volunteers. The obtained data were compared with the main indicators of complete and biochemical blood tests. Results. The correlations were found between the thyroid status indicators and parameters of complete and biochemical blood tests in males with AIPD, which are normally absent. Changes in the thyroid hormones levels, hematological and biochemical blood parameters occurred proportionally to each other, and the degree of these changes depended on the severity of the inflammatory reaction. Males with AIPD and euthyroidism or nonthyroidal illness syndrome (NTIS) of types I and V did not differ by total protein (p=0.24) and albumin (p=0.2) levels, which were higher than in primary hypothyroidism and NTIS of type II (p=0.001 and p=0.002). The lowest concentration of total cholesterol was observed in primary hypothyroidism (p=0.013). The low-density lipoprotein levels did not differ in patients with primary hypothyroidism, NTIS of type I and type II (p=0.39) and were lower than in case of euthyroidism and NTIS of type V (p=0.004). Conclusion. In males with AIPD the functional status of the thyroid gland is associated with the severity of inflammation. Thyroid hormones are involved in the pathogenesis of metabolic disorders in AIPD. The types of thyroid function in AIPD are associated with varying degrees of severity of protein and lipid metabolism disorders.