Moderate Spectrum Genes Associated With Breast Cancer |Biomedgrid

Worldwide, breast cancer is the most common form of malignancy among women. One out of every twelve women on the west side suffers breast cancer at some point in their lifetimes. According to one estimate, 5 % to 10% of all breast cancer cases in women are linked to genetic defencelessness caused to mutations in autosomal dominant genes. Genetic mutations of genes BRCA 1 and BRCA 2 are associated with an increased risk of breast cancer. Triple-negative breast cancer can potentially be caused by a mutation in the TP53 gene. However, most incidences of breast cancer are linked to moderate penetrance genes such as CTLA-4, Pik3ca, Kiss- 1, TPD52, and PTEN which are likewise mutated in practically every group. In the present review, we will discuss the low spectrum of mutations related to breast cancer.